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Application of chlorotrimethylsilane in Pictet–Spengler reaction

Monatshefte f ,r Chemie - Chemical Monthly 2012, 143 (11), 1507-1517

DOI: 10.1007/s00706-012-0804-7

Ryabukhin S.; Panov D.; Plaskon A.; Tolmachev A.; Smaliy R.

Chlorotrimethylsilane has been found to be an efficient condensing agent in the Pictet–Spengler reaction, affording an extremely straightforward synthetic route to tetrahydro-β-carboline derivatives and their analogs. The applicability of the method has been studied, and a representative library of structurally diverse products has been created.

Application of chlorotrimethylsilane in Pictet–Spengler reaction

Ryabukhin S.; Panov D.; Plaskon A.; Tolmachev A.; Smaliy R.
Monatshefte für Chemie - Chemical Monthly 2012, 143 (11), 1507-1517
DOI: 10.1007/s00706-012-0804-7

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