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A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides

Synthesis , 2011, 22, 3669-3674

DOI: 10.1055/s-0030-1260223

Zhersh S.; Buryanov V. V.; Karpenko O. V.; Grygorenko O. O.; Tolmachev A. A.

An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides was designed and synthesized. The library consists of nine members that are derivatives of azetidine, pyrrolidine, and piperidine. These compounds were prepared in 19-88% total yields on multigram scale starting from the corresponding Cbz-protected amino alcohols.

A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides

Zhersh S.; Buryanov V. V.; Karpenko O. V.; Grygorenko O. O.; Tolmachev A. A.
Synthesis 2011, 22, 3669-3674
DOI: 10.1055/s-0030-1260223

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