Synthesis of β-fluoro-β-proline
Tetrahedron Lett. , 2011, 52 (12), 1300-1302
A synthetic strategy towards the novel amino acid β-fluoro-β-proline, a fluorinated analogue of β-proline, is elaborated. The synthesis commences from commercially available methyl 2-fluoroacrylate and involves three steps. The overall yield of β-fluoro-β-proline is 57%.
Yarmolchuk V. S.; Mykhailiuk P. K.; Komarov I. V.
Tetrahedron Lett. 2011, 52 (12), 1300-1302