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Facile Synthesis of 2-(2-Ethoxy-1,2-dioxoethyl)azoles

Synthesis , 2011, 10, 1633-1637

DOI: 10.1055/s-0030-1260003

Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Mykhailiuk P. K.; Zaporozhets O. A.; Tolmachev A. A.

C-Acylation of N-substituted imidazoles with ethyl oxalyl chloride in the presence of N,N-diisopropylethylamine as a base afforded 2-(2-ethoxy-1,2-dioxoethyl)imidazoles in 83-95% yield. Application of this synthetic protocol to thiazoles and triazoles led to the corresponding 2-ethoxy-1,2-dioxoethyl derivatives in 40-51% yield.

Facile Synthesis of 2-(2-Ethoxy-1,2-dioxoethyl)azoles

Geraschenko O. V.; Khodakovskiy P. V.; Shishkin O. V.; Mykhailiuk P. K.; Zaporozhets O. A.; Tolmachev A. A.
Synthesis 2011, 10, 1633-1637
DOI: 10.1055/s-0030-1260003

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