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Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine

Synthesis , 2011, 01, 119-122

DOI: 10.1055/s-0030-1258323

Bezdudny A. V.; Klukovsky D.; Simurova N.; Mykhailiuk P. K.; Shishkin O. V.; Pustovit Y. M.

2-(Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch.

Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine

Bezdudny A. V.; Klukovsky D.; Simurova N.; Mykhailiuk P. K.; Shishkin O. V.; Pustovit Y. M.
Synthesis 2011, 01, 119-122
DOI: 10.1055/s-0030-1258323

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