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A Facile Synthesis of 1-Chloro-2,2,2-trifluoroethyl Sulfides

Synthesis , 2010,07, 1159-1165

DOI: 10.1055/s-0029-1219232

Pustovit Y.; Alexeenko A.; Trofymchuk S.; Lukin O.; Tolmachev A. A.

A facile synthesis of structurally diverse 1-chloro-2,2,2-trifluoroethyl sulfides from readily available 1-bromo-1-chloro-2,2,2-trifluoroethane (Halothane®) and various aliphatic and aromatic thiols in the presence of sodium dithionite/sodium bicarbonate is described. The synthetic utility of the prepared sulfides is illustrated by the synthesis of biologically potent heterocycles and by their electrophilic reactions with thiophene.

A Facile Synthesis of 1-Chloro-2,2,2-trifluoroethyl Sulfides

Pustovit Y.; Alexeenko A.; Trofymchuk S.; Lukin O.; Tolmachev A. A.
Synthesis 2010, 07, 1159-1165
DOI: 10.1055/s-0029-1219232

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