Regioselective Synthesis of Novel Perfluoroalkylated Fused Pyridines and 3-(Aminomethylene)thiochroman-4-ones from 3-(Perfluoroalkanoyl)thiochromenones and Amines

The regioselectivity of reactions of 3-(perfluoroacyl)-4H-thiochromen-4-ones with a range of hetaryl, aryl, and alkyl amines was examined. The reactions provide ready access to polyfluoroalkylated fused pyridines and thiochromen-4-ones.

Kotljarov A.; Sevenard D. V.; Iaroshenko V. O.; Irgashev R. A.; Volochnyuk D. M.; Langer P.; Tolmachev A. A.; Sosnovskikh V. Y.
Synthesis 2010, 04, 671-677
DOI: 10.1055/s-0029-1218586