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Noncatalytic Electrophilic Oxyalkylation of 3-Aminopyrazoles with 2-(Trifluoroacetyl)-1,3-azoles

Synthesis , 2010, 07, 1195-1199

DOI: 10.1055/s-0029-1218657

Khodakovskiy P. V.; Mykhailiuk P. K.; Volochnyuk D. M.; Tolmachev A. A.

2-(Trifluoroacetyl)-1,3-azoles reacted with 3-aminopyrazoles to give the corresponding trifluoromethyl-substituted alcohols. The conditions required for the reaction and the yields of the products were highly dependent on the electronic nature of the both the 1,3-azole and the 3-aminopyrazole units.

Noncatalytic Electrophilic Oxyalkylation of 3-Aminopyrazoles with 2-(Trifluoroacetyl)-1,3-azoles

Khodakovskiy P. V.; Mykhailiuk P. K.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2010, 07, 1195-1199
DOI: 10.1055/s-0029-1218657

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