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4-Fluoro-2,4-methanoproline

Org. Lett. , 2009, 11 (24), 5674-5676

DOI: 10.1021/ol902381w

Tkachenko A. N.; Radchenko D. S.; Mykhailiuk P. K.; Grygorenko O. O.; Komarov I. V.

The first fluorinated analogue of the naturally occurring 2,4-methanoproline, 4-fluoro-2,4-methanoproline, has been synthesized in five steps from commercially available methyl 2-fluoroacrylate through a photochemical cyclization as a key step in generating a 2-azabicyclo[2.1.1]hexane skeleton.

4-Fluoro-2,4-methanoproline

Tkachenko A. N.; Radchenko D. S.; Mykhailiuk P. K.; Grygorenko O. O.; Komarov I. V.
Org. Lett. 2009, 11 (24), 5674-5676
DOI: 10.1021/ol902381w

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