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Decarboxylative Aldol-Type Reaction of 2-(Trifluoroacetyl)-1,3-diazoles with Activated Acetic Acids

Synthesis , 2009, 07, 1099-1104

DOI: 10.1055/s-0028-1087985

Khodakovskiy P. V.; Volochnyuk D. M.; Tolmachev A. A.

The highly electrophilic ketones 2-(trifluoroacetyl)-1,3-diazoles easily undergo a decarboxylative aldol-type reaction with activated acetic acids to afford heterocyclic trifluoromethyl-substituted alcohols bearing various functionalities.

Decarboxylative Aldol-Type Reaction of 2-(Trifluoroacetyl)-1,3-diazoles with Activated Acetic Acids

Khodakovskiy P. V.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2009, 07, 1099-1104
DOI: 10.1055/s-0028-1087985

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