Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs
Synth. Commun. , 2008, 38 (17), 3032-3043
A facile one-pot method for the synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids and their heterocyclic analogs based on the tert-amino effect. A set of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids was readily prepared starting from various ortho-dialkylaminoaldehydes and Meldrum's acid using Me3SiCl in dimethylformamide (DMF) solution.
Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Pipko S. E.; Tolmachev A. A.
Synth. Commun. 2008, 38 (17), 3032-3043