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One-pot synthesis of β-imidazolylpropionamides

Tetrahedron Lett. , 2008, 49 (25), 3997-4002

DOI: 10.1016/j.tetlet.2008.04.096

Ryabukhin S. V.; Granat D. S.; Khodakovskiy P. V.; Shivanyuk A. N.; Tolmachev A. A.

New efficient one-pot methodology for the preparative synthesis of β-imidazolylpropionamides was elaborated. It is based on the addition of imidazole to the activated double bond of the intermediate acrylimidazolide in the reaction between diverse acrylic acids and different amines promoted by CDI. A set of structurally and functionally diverse β-imidazolylpropionamides was obtained in high preparative yields.

One-pot synthesis of β-imidazolylpropionamides

Ryabukhin S. V.; Granat D. S.; Khodakovskiy P. V.; Shivanyuk A. N.; Tolmachev A. A.
Tetrahedron Lett. 2008, 49 (25), 3997-4002
DOI: 10.1016/j.tetlet.2008.04.096

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