Chlorotrimethylsilane-Mediated Synthesis of 2-Aryl-1-chloro-1-heteroarylalkenes
Synthesis , 2007, 20, 3163-3170
The condensation of (chloromethyl)heterarenes with aromatic aldehydes was investigated, resulting in a simple and flexible general procedure for the synthesis of 2-aryl-1-chloro-1-heteroarylalkenes. The best reaction conditions were found to be heating in N,N-dimethylformamide in the presence of chlorotrimethylsilane as a promoter and water-scavenger.
Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2007, 20, 3163-3170