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Combinatorial Knoevenagel Reactions

J. Comb. Chem. , 2007, 9 (6), 1073-1078

DOI: 10.1021/cc070073f

Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Pipko S. E.; Shivanyuk A. N.; Tolmachev A. A.

Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11 000 compounds of high structural and functional diversity.

Combinatorial Knoevenagel Reactions

Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Pipko S. E.; Shivanyuk A. N.; Tolmachev A. A.
J. Comb. Chem. 2007, 9 (6), 1073-1078
DOI: 10.1021/cc070073f

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