Combinatorial Knoevenagel Reactions
J. Comb. Chem. , 2007, 9 (6), 1073-1078
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the Knoevenagel condensations of aromatic aldehydes with various methylene active compounds. High yields and a simple workup of target compounds enables the facile generation of combinatorial libraries comprising 11 000 compounds of high structural and functional diversity.
Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Pipko S. E.; Shivanyuk A. N.; Tolmachev A. A.
J. Comb. Chem. 2007, 9 (6), 1073-1078