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  • Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1H-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1H-benzimidazoles

A New Synthetic Approach to Pyrrolo[3,4-a]indolizines

Synthesis , 2006, 02, 349-353

DOI: 10.1055/s-2005-918510

Tereshchenko A. D.; Sysoiev D. A.; Tverdokhlebov A. V.; Tolmachev A. A.

2-Pyridineacetonitrile was found to react with 1,3-dichloro-2-propanone in the presence of chlorotrimethylsilane yielding 2-chloromethyl-1-indolizinecarbonitrile. The chlorine atom in the prepd. indolizine was replaced by various nucleophiles including substituted anilines. Treatment of 2-(arylamino)methyl-1-indolizinecarbonitriles with hydrochloric acid resulted in 2-aryl-2,3-dihydro-1H-pyrrolo[3,4-a]indolizine-1-iminium chlorides.

A New Synthetic Approach to Pyrrolo[3,4-a]indolizines

Tereshchenko A. D.; Sysoiev D. A.; Tverdokhlebov A. V.; Tolmachev A. A.
Synthesis 2006, 02, 349-353
DOI: 10.1055/s-2005-918510

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