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Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring

Chem. Heterocycl. Compd. 2019, 55 (9), 893‑896

DOI: 10.1007/s10593-019-02554-x

Tsizorik N.; Hrynyshyn Y.; Musiychuk A.; Bol’but A.; Vovk M.

A reaction of 4-chloropyrazolo[1,5-a]pyrazines with tert-butyl cyanoacetate proceeded via the formation of tert-butyl cyano(pyrazolo-[1,5-a]pyrazin-4(5H)-ylidene)ethanoates as intermediates and led to pyrazolo[1,5-a]pyrazin-4-ylacetonitriles, which were used to obtain derivatives of a new pyrazolo[1,5-a]pyrido[2,1-c]pyrazine system.

Synthesis of pyrazolo[1,5-a]pyrazin-4-ylacetonitriles and their annulation with pyridine ring

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