Synthesis of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines by palladium-catalyzed Suzuki–Miyaura cross coupling
Chem. Heterocycl. Compd. 2019, 55 (11), 1070-1074
4-Bromopyrazolo[1,5-a]pyrazines react with aryl(hetaryl)boronic acids in the presence of catalytic amounts of Pd(dppf)Cl2·CH2Cl2 and an excess of Cs2CO3 in the MeCN–H2O, 9:1 solvent system with the formation of 4-aryl(hetaryl)pyrazolo[1,5-a]pyrazines.