Building Blocks Catalog

300 Thousand compounds in stock

Original and unique

Make-on-demand
Building Blocks

1B novel building blocks

Reliable supply

Custom Synthesis

Over 650 highly skillful chemists

Unique synthesis technologies

Library Synthesis

48B Billion REAL compounds and

Custom Library Synthesis

FTE Chemistry Support

On site access to all Enamine stock BB’s

Highly flexible arrangements

2 000 new building blocks are synthesized monthly. Here is an important update to our MedChem Highlights from February 2024

Recent News

  • 27 March 2024   Press Release

    Enamine Announces Expansion of Its Library Synthesis Capabilities

    March, 2024, Kyiv, Ukraine. Enamine Ltd, the global leader in supplying small molecules and early drug discovery services, announces the expansion of its library synthesis capabilities with a focus on Enamine REAL compounds to further support the growing demands of agricultural and pharmaceutical companies, research institutes, and drug discovery centers.

  • 01 March 2024   News

    Enamine and Genez International Announce Strategic Collaboration to Launch ...

    We are excited to announce a strategic collaboration between Enamine, the world's leading provider of chemical building blocks, compound libraries, and biology services, and Genez International, a prominent enterprise with 15 years of experience in cross-border supply management, biopharmaceutical research and development, semiconductor equipment, and high-definition digital imaging systems.

  • 21 February 2024   Press Release

    Cresset Announces Global Collaboration With Enamine on New Virtual ...

    Cresset recently announced a collaboration with Enamine, the world’s leading provider of chemical building blocks and drug discovery services to develop innovative new solutions for the early drug discovery process.

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At present, many suppliers of the building blocks for drug design offer large selection of the unnatural amino acids. Enamine committed itself to create a library of the unusual amino acids which would differ from the available on the market. First, we offer a number of racemic α-amino acids at the very reasonable prices. The price category, together with extremely wide chemical diversity, makes these amino acids especially attractive in lead discovery by HTS. Examples illustrating chemical diversity of this set can be found below:

Other principles were used when compiling a set of conformationally restricted amino acids. The peptidomimetics obtained on the basis of conformationally restricted unnatural amino acids are expected to be biologically active due to their better preorganization resulting in stronger interaction with target biomolecules. These amino acids are optically pure (where applicable), and often can be supplied in both enantiomeric forms. N-protected derivatives, ready for the automated peptide synthesis are also available. Large selection of cyclic and polycyclic amino acids alows for variation of the geometry of the peptidomimetics in a vide range, fine-tuning the structure to the need of structure-based drug design. Low molecular mass and favourable lipophilicity make them useful in the fragment-based lead discovery. Some examples are shown below:

Yet another subset of the Enamine Amino Acid Selection Database consists of conformationally restricted β-, γ- and ω- amino acids. Their use in the peptidomimetic design has been shown to lead to extremely unusual structural consequences and promising biological activity, see, for example, and references therein. Here, too, chiral compounds are available as single enantiomers of high optical purity. In most cases, these amino acids are available in protected form ready for peptide synthesis.

Finally, Enamine offers a vide variety of the fluorine-substituted α- and γ- amino acids. These compounds can be used in drug design and also as biomarkers, 19F labels in NMR-spectroscopy. In the synthesis of the fluorine-substituted amino acids our chemists use the experience in the fluorine chemistry acquired in cutting-edge research carried out at the Ukrainian scientific institutions. Examples:

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