Anal Bioanal Chem 2026, 418 (1), 1-3
DOI: 10.1007/s00216-025-06224-0
Kozytskyi A. V.; Levchenko K. V.
Spirocyclic frameworks, especially those incorporating cyclopropane rings, are increasingly recognized as valuable motifs in organic chemistry and drug discovery. Their rigid, three-dimensional structures and high strain energy contribute to unique reactivity profiles and favorable pharmacokinetic properties. These sp3-rich systems help expand chemical space and are often employed to improve solubility, metabolic stability, and target selectivity in drug candidates
In this challenge, we focus on a spirocyclic cyclopropane and we will attempt to distinguish between its two stereoisomers. using only their 1H-NMR spectra