Chem. Heterocycl. Compd. 2019, 55 (8), 692‑694
DOI: 10.1007/s10593-019-02521-6
Grygorenko O.; Melnykov K.
Recent advances in synthetic and medicinal chemistry of saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties are surveyed, including results published in the last decade. In particular, gem-difluoro-substituted derivatives of azaspiro[2.n]alkanes, azaspiro[3.n]alkanes, azaspiro[4.5]decane, and other spirocyclic scaffolds are discussed.
