Synthesis 2004, 14, 2317-2322
DOI: 10.1055/s-2004-831178
Tverdokhlebov A. V.; Andrushko A. P.; Resnyanska E. V.; Tolmachev A. A.
6-Aryl-2,3-dihydro-3-oxopyrrolo[2,1-b]thiazole-7-carboxylic acids ethyl esters were prepared by refluxing 2-[3-(2-aryl-2-oxoethyl)-4-oxo-2-thiazolidinylidene]acetic acid ethyl esters in POCl3. An amination of the obtained pyrrolo[2,1-b]thiazole derivatives with primary aliphatic amines was found to yield N-alkyl-2-[(4-aryl-3-ethoxycarbonyl-2-pyrrolyl)thio]acetamides and -propanamides.