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ACS Org Inorg Au 2024, 4 (4), 424-431

DOI: 10.1021/acsorginorgau.4c00028

Holovach S.; Poroshyn I.; Melnykov K. P.; Liashuk O. S.; Pariiska O. O.; Kolotilov S. V.; Rozhenko A. B.;

Parallel Minisci reactions of nonfluorinated and gem-difluorinated C4–C7 cycloalkyl building blocks (trifluoroborates and carboxylic acids) with a series of electron-deficient heterocycles were studied. A comparison of the reaction’s outcome revealed better product yields in the case of carboxylic acids as the radical precursors in most cases, albeit these reagents were used with three-fold excess under optimized conditions. The nature of the heterocyclic core was found to be important for successful incorporation of the cycloalkyl fragment. The impact of the CF2 moiety on the oxidation potential of fluorinated cycloalkyl trifluoroborates and the reaction outcome, in general, was also evaluated.

 

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