Facile Synthesis of Fluorinated Purines and Thiapurines

The reaction of 2-(dialkylamino)-1,3-thiazol-4-amines and 1,2-dimethyl-1H-imidazol-5-amine with aryl isocyanates, α-chloroalkyl isocyanates, N-(alkoxycarbonyl)imidoyl chlorides and 2,4,6-tris(trifluoromethyl)-1,3,5-triazine leads to thiapurines and purines containing trifluoromethyl groups in the 2- and 6-positions of the pyrimidine ring.

Iaroshenko V. O.; Volochnyuk D. M.; Yan W.; Vovk M. V.; Boiko V. J.; Rusanov E. B.; Groth U. M.; Tolmachev A. A.
Synthesis 2007, 21, 3309-3318
10.1055/s-2007-990843