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Synthesis , 2007, 20, 3163-3170

DOI: 10.1055/s-2007-990791

Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Tolmachev A. A.

The condensation of (chloromethyl)heterarenes with aromatic aldehydes was investigated, resulting in a simple and flexible general procedure for the synthesis of 2-aryl-1-chloro-1-heteroarylalkenes. The best reaction conditions were found to be heating in N,N-dimethylformamide in the presence of chlorotrimethylsilane as a promoter and water-scavenger.

Chlorotrimethylsilane-Mediated Synthesis of 2-Aryl-1-chloro-1-heteroarylalkenes

Ryabukhin S. V.; Plaskon A. S.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2007, 20, 3163-3170
DOI: 10.1055/s-2007-990791

 

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