CF₃-substituted 1,3-dicarbonyl compounds in the Biginelli reaction promoted by chlorotrimethylsilane

Trifluoromethyl-1,3-diones were investigated as reactants in the Biginelli reaction promoted by Me₃SiCl. The dependence of the reaction pathway on the nature of substituent at the α-position to the carbonyl group was established. A set of new CF₃-containing dihydropyrimidine(thi)one derivatives was obtained. A number of novel 5-CF₃CO dihydropyrimidine(thi)ones were synthesized.

Ryabukhin S. V.; Plaskon A. S.; Ostapchuk E. N.; Volochnyuk D. M.; Shishkin O. V.; Tolmachev A. A.
J. Fluorine Chem. 2008, 129 (7), 625-631
DOI: 10.1016/j.jfluchem.2008.05.004