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Synthesis , 2012, 44 (17), 2739-2742

DOI: 10.1055/s-0032-1316985

Alekseenko A. N.; Klukovsky D.; Lukin O.; Mykhailiuk P. K.; Shishkin O. V.; Pustovit Y. M.

An improved synthesis of 2-, 3-, and 4-trifluoromethylcyclohexylamines on a multigram scale via PtO2-mediated hydrogenation of the corresponding trifluoromethylanilines in trifluoroacetic acid at room temperature under atmospheric pressure is reported. The hydrogenation occurred with a remarkable stereoselectivity favoring the formation of cis-isomers.

An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines

Alekseenko A. N.; Klukovsky D.; Lukin O.; Mykhailiuk P. K.; Shishkin O. V.; Pustovit Y. M.
Synthesis 2012, 44 (17), 2739-2742
DOI: 10.1055/s-0032-1316985

 

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