Angew. Chem. Int. Ed. Engl. 2026, in press
DOI: 10.1002/anie.7155694
Tverdokhlebov A. V.; Resnyanska E. V.; Zavada A. V.; Tolmachev A. A.; Kostyuk A. N.; Chernega A. N.
Since 1947, the Balz–Schiemann reaction has remained the most popular method for the synthesis of meta-fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta-fluoropyridines has now been developed on the basis of a 1,3-disconnection strategy.