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Synthesis , 2008, 07, 1069-1077

DOI: 10.1055/s-2008-1066988

Plaskon A. S.; Ryabukhin S. V.; Volochnyuk D. M.; Tolmachev A. A.

The cyclization of 3-formylchromone with a variety of 2-methylpyrimidin-4(3H)-ones promoted by chlorotrimethylsilane was investigated. A simple and flexible general procedure for the synthesis of a series of fused pyrido[1,2-a]pyrimidin-4-ones is proposed. A set of functionally and structurally diverse pyrido[1,2-a]pyrimidin-4-ones were obtained in high yields.

A New One-Step Route for the Synthesis of Fused Pyrido[1,2-a]pyrimidin-4-ones

Plaskon A. S.; Ryabukhin S. V.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2008, 07, 1069-1077
DOI: 10.1055/s-2008-1066988

 

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