CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones
Tetrahedron Lett. 2017, 58 (13), 1308‑1311
DOI: 10.1016/j.tetlet.2017.02.046
Sokolenko L. V.; Yagupolskii Y. L.; Kumanetska L. S.; Marrot J.; Magnier E.; Lipetskij V. O.; Kalinin I. V.
Methyl 3-(dimethylamino) acrylates containing trifluoromethylsulfenyl-, trifluoromethylsulfinyl-, and trifluoromethylsulfonyl groups were synthesized and their utility demonstrated by reactions with aliphatic and aromatic amidines to produce 2,5-substituted 4(3H)-pyrimidones. Cyclization reactions of enaminones with urea or thiourea led to 5-substituted uracil or 2-thiouracil derivatives, respectively.
