Direct Noncatalytic Electrophilic Trifluoroacetylation of Electron-Rich Pyrazoles
Synthesis 2014, 46 (09), 1254-1260
DOI: 10.1055/s-0033-1340840
Yarmoliuk D. V.; Arkhipov V. V.; Stambirskyi M. V.; Dmytriv Y. V.; Shishkin O. V.; Tolmachev A. A.; Mykhailiuk P. K.
Electron-rich N-substituted pyrazoles smoothly reacted with trifluoroacetic anhydride in pyridine to form the corresponding trifluoromethyl ketones in good yields.
