Unexpected result in the reaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of 1,3-dicarbonyl compounds. synthesis of pyrimidine-5-carboxamide derivatives
Chem. Heterocycl. Compd. , 2013, 49 (3), 440-451
DOI: 10.1007/s10593-013-1266-5
Dotsenko V. V.; Frolov K. A.; Krivokolysko S. G.; Polovinko V. V.
The interaction of 3-amino-3-thioxopropanamides with 2-anilinomethylene derivatives of dimedone, 1,3-cyclohexanedione and Meldrum's acid led to the formation of 2-(2-amino-2-oxoethyl)-6-thioxo-1,6-dihydropyrimidine-5-carboxamides. The latter were alkylated in alkaline medium with the formation of 4-(alkylthio)pyrimidine-5-carboxamide derivatives.
Dotsenko V. V.; Frolov K. A.; Krivokolysko S. G.; Polovinko V. V.
Chem. Heterocycl. Compd. 2013, 49 (3), 440-451
DOI: 10.1007/s10593-013-1266-5