3-(Dichloroacetyl)chromone; A New Building Block for the Synthesis of Formylated Purine Isosteres: Design and Synthesis of Fused α-(Formyl)pyridines
Synthesis , 2011, 03, 469-479
DOI: 10.1055/s-0030-1258364
Iaroshenko V. O.; Mkrtchyan S.; Ghazaryan G.; Hakobyan A.; Maalik A.; Supe L.; Villinger A.; Tolmachev A.; Ostrovskyi D.; Sosnovskikh V. Y.; Ghochikyan T. V.; Langer P.
The first synthesis of 3-(dichloroacetyl)chromone from 3-(dimethylamino)-1-(2-hydroxyphenyl)propen-1-one and dichloroacetyl chloride is described. The reaction of electron-rich aminoheterocycles with 3-(dichloroacetyl)chromone provides a set of diverse fused pyridines bearing the CHCl2-substituent at the α-position of the pyridine core. Subsequent hydrolysis leads to the formation of annulated α-(formyl)pyridines.
Iaroshenko V. O.; Mkrtchyan S.; Ghazaryan G.; Hakobyan A.; Maalik A.; Supe L.; Villinger A.; Tolmachev A.; Ostrovskyi D.; Sosnovskikh V. Y.; Ghochikyan T. V.; Langer P.
Synthesis 2011, 03, 469-479
DOI: 10.1055/s-0030-1258364