Synthesis of 3-(Pyrimidinyl)pyrrole Derivatives

Alkylation of 4,6-dimethyl-2- and 2,6-dimethyl-4-pyrimidineacetonitrile with chloroacetyl anilides gave 4-(4,6-dimethyl-2-pyrimidinyl)- and 4-(2,6-dimethyl-4-pyrimidinyl)-5-amino-2,3-dihydro-1-arylpyrrol-2-ones, resp. Corresponding isomeric compds., 5-amino-4-pyrimidinyl-2,3-dihydropyrrol-3-ones were obtained by Claisen condensation of the mentioned pyrimidineacetonitriles with N-Boc-α-amino acid imidazolides, followed by removal of the protecting group, accompanied by simultaneous ring closure.

Nestorak I. Y.; Tverdokhlebov A. V.; Tolmachev A. A.; Volovenko Y. M.
Heterocycles 2010, 81 (3), 611-623
DOI: 10.3987/COM-09-11881