Noncatalytic Electrophilic Oxyalkylation of Anilines with 2-Trifluoroacetyl-1,3-benzothiazole
Synthesis , 2010, 10, 1633-1638
DOI: 10.1055/s-0029-1218712
Khodakovskiy P. V.; Mykhailiuk P. K.; Volochnyuk D. M.; Tolmachev A. A.
2-Trifluoroacetyl-1,3-benzothiazole reacts with anilines to form the corresponding trifluoromethyl-substituted alcohols. The reaction regioselectivity (ortho/para) was shown to depend strongly on the structure of the aniline. meta-Substituted anilines tend to form the corresponding ortho-substituted products, in contrary to the previous literature data.
Khodakovskiy P. V.; Mykhailiuk P. K.; Volochnyuk D. M.; Tolmachev A. A.
Synthesis 2010, 10, 1633-1638
DOI: 10.1055/s-0029-1218712