Angew Chem Int Ed Engl 2024, 63 (19), e202319831
DOI: 10.1002/anie.202319831
Levterov V.; Panasiuk Y.; Shablykin O.; Stashkevych O.; Sahun K.; Rassokhin A.; Sadkova I. et al.
We have developed a general and practical approach towards 2-oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2-Oxabicyclo[2.1.1]hexanes have been incorporated into the structure of five drugs and three agrochemicals, and validated biologically as bioisosteres of ortho- and meta-benzenes.