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A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

Angew. Chem. Int. Ed. 2022, e202205103

DOI: 10.1002/anie.202205103

Bychek R.; Mykhailiuk P.

After more than 20 years of trials, a practical scalable approach to fluoro-substituted bicyclo[1.1.1]pentanes (F-BCPs) has been developed. The physicochemical properties of the F-BCPs have been studied, and the core was incorporated into the structure of the anti-inflammatory drug Flurbiprofen in place of the fluorophenyl ring.

A Practical and Scalable Approach to Fluoro-Substituted Bicyclo[1.1.1]pentanes

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