Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico-Chemical Properties
Eur. J. Org. Chem. 2021, 2021 (47), 6591‑6603
Multigram synthesis of saturated heterocyclic dimethylphosphine oxides (derivatives of azetidine, pyrrolidine, piperidine, and morpholine) – advanced building blocks for medicinal chemistry – as well as their physico-chemical properties (pKa, logP, and Sw) are disclosed.