Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances
Eur. J. Org. Chem. 2021, 2021 (47), 6478-6510
Emerging building blocks for medicinal chemistry are discussed, with a special focus on recent efforts towards their synthesis. Saturated (hetero)aliphatic boronates, sulfonyl fluorides, sulfinates, non-classical sp3-enriched benzene isosteres, bicyclic morpholine, piperidine, or piperazine analogues, as well as gem-difluorinated cycloalkanes (a deliberately selected example of emerging fluorinated motifs) are covered.