A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides
Synthesis , 2011, 22, 3669-3674
An approach to the synthesis of conformationally restricted saturated heterocyclic sulfonyl chlorides is described. Being guided by the principle of diversity-oriented conformational restriction, a mini-library of saturated heterocyclic sulfonyl chlorides was designed and synthesized. The library consists of nine members that are derivatives of azetidine, pyrrolidine, and piperidine. These compounds were prepared in 19-88% total yields on multigram scale starting from the corresponding Cbz-protected amino alcohols.
Zhersh S.; Buryanov V. V.; Karpenko O. V.; Grygorenko O. O.; Tolmachev A. A.
Synthesis 2011, 22, 3669-3674