With development of on-line chemical directories acquiring necessary reagents and building blocks for day-to-day research activity has become a technical routine. Many thousands of building blocks are now available in the market and sub-structure search can efficiently provide a selection of reagents to buy. However, this approach might be limited. With over 80,000 building blocks synthesized and now available from our stock we are a recognized leader in the market. Our catalog features versatile building block classes and adds 1,000 products each month. Although they all are available for purchase through EnamineStore and many public or corporate chemical databases we wanted to gather together the most interesting and recently prepared building blocks to provide a series of useful guides to a novel and innovative chemistry. First five brochures have been published to highlight our rich collections of Advanced Morpholine Analogues, Bicyclic Aliphatic Amines, Fluorinated Aliphatic Amines, Isocyanates, Isothiocyanates, and Trifluoroethyl Carbamates, and Sulfonyl Chlorides and other Sulfonylating Agents.