Recently Enamine has further improved the high-throughput synthesis workflow used for preparation of compounds offered through the REAL Database. Removal of production bottlenecks, application of optimized technological solutions and expansion of high performance preparative flash chromatography unit allowed us to shorten entire production cycle to 12-14 days. Currently we are able to produce up to 2,000 samples per month using this optimized procedure. 90% feasibility rate can be achieved after a single production cycle for typical compound sets. Compounds synthesized via the enhanced scheme can be delivered within 3 weeks after acceptance of an order.