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Hit Locator Library

Designed to represent entire 2.8 M Screening Collection within lead-like space

234 240 compounds

Hit Locator Library (HLL) is a large diverse set of 234 240 novel screening compounds, designed to represent the entire Enamine’s screening collection.

All compounds from HLL were synthesized within the last 10 years, providing competitive advantage to access the latest compounds in primary screening campaigns.

HTS at Enamine allows an immediate access the entire HLL with low-cost, access-only fee, including hit confirmation from fresh powders and broad possibilities for express hit expansion either from stock, or from REAL database.

Hit Locator Library contains 234 240 compounds and is available for prompt supply in convenient pre-plated formats

Catalog ID
Compounds
Amount
Formats
Price

Catalog ID

HLL-234-0-Z-2

Compounds

234 240
183 plates

Amount

≤ 150 nL of DMSO solutions

Formats

1536-well microplates, LDV
1280 cmpds per plate; first four and last four columns empty

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Catalog ID

HLL-234-10-Y-10

Compounds

234 240
732 plates

Amount

10 µL of 10 mM of DMSO solutions

Formats

384-well microplates, Grainer #781280
320 cmpds per plate; 1, 2 and 23, 24 columns empty

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Catalog ID

HLL-234-20-Y-10

Compounds

234 240
732 plates

Amount

20 µL of 10 mM of DMSO solutions

Formats

384-well microplates, Greiner/Labcyte
320 cmpds per plate; 1, 2 and 23, 24 columns empty

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Request a quote

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

Library design

New approach to the design our largest screening library aims to deliver most reliable source of initial hits. Each compound in the library passed stringent MedChem filters, QC control and visual inspection of a substance. Sophisticated construction of this HTS Library allow to get initial SAR data immediately after a first screen and will help you to determine safe hits, which you can follow more secure than any other from commercial diversity libraries. The main focus at medicinal chemistry hand was fixed on the lead-like molecules to give more space for evolution of identified hits. At the same time, we were trying to focus on robust chemistry, which should not bring a troubles with synthesis of a scaffold or its derivatisation. Our deep knowledge in synthetic chemistry already over 25 years’ experience allowed us to rate molecules by synthetic feasibility, which has been used as additional evaluation in the design of the largest Enamine Screening Library.

Key features

  • No singletons, at least 3 compounds per cluster
  • Immediate SAR data, scaffold-secured
  • Represents entire Enamine Compound Collection
  • Lead-like molecules only
  • Hit resupply from dry powders in 90%+ cases

Along with all industry affiliated MedChem filters, sieve visual control of the core scaffolds (over 37k) have been applied. We believe that our effort will bring you a valuable hits. Some examples are represented below

Example of a cluster series

Cluster 371

Cluster 3733

Molecular properties

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