CLOUD
The comprehensive Drug Collection
293 compounds
To date no commercially available compound collection covered all drug classes, resulting in complications in combinatorial screening attempts. We collaborated with a group of researchers at CeMM and collected a condensed screening set of 293 small molecules representing the entire target and chemical space of all FDA-approved drugs. The CeMM Library of Unique Drugs (CLOUD) covers prodrugs and active forms at pharmacologically relevant concentrations and is ideally suited for combinatorial studies. Recent publication [1] provides evidences of successful drug repurposing by pairwise compound screening from CLOUD collection in cancer cell viability assay. The findings highlight that refined chemical library CLOUD is a powerful tool for drug repurposing and evaluation of new substances suitable for all high-content and high-throughput assays.
CLOUD is now available for immediate supply in the following most popular pre-plated formats
Item
1
Catalog ID
CLOUD-Y-0
Compounds №
293
Amount
≤ 1 µL of DMSO solutions at pharmacologically relevant concentrations or at 10 mM concentration
Format
384-well eco-qualified assay ready microplates, Greiner/Labcyte
Item
2
Catalog ID
CLOUD-Y/X-10
Compounds №
293
Amount
10 µL of 10 mM or at physiologically relevant concentrations DMSO solutions
Format
384-well or 96-well plates, eco-compatible
Item
3
Catalog ID
CLOUD-Y/X-50
Compounds №
293
Amount
50 µL of 10 mM or at physiologically relevant concentrations DMSO solutions
Format
384-well or 96-well plates, eco-compatible
Item
4
Catalog ID
CLOUD-Y/X-100
Compounds №
293
Amount
100 µL of 10 mM or at physiologically relevant concentrations DMSO solutions
Format
384-well eco-qualified assay ready microplates, Greiner/Labcyte
*Y - 384-well plate *X - 96-well plate
Key features
- Covers all therapeutically significant space of approved drugs.
- Contains prodrugs and active metabolites at pharmacologically relevant concentrations.
- Ideally applicable for combinatorial assays to study new drug combinations.
- Most structurally diverse drug library among commercially available collections.
- Immediately accessible in convenient pre-plated formats with carefully prepared detailed documentation. The library can be also made in any customized ready-to-screen formats.
Examples of drugs in the library
CLOUD147Iloprost
CLOUD019Clopidogrel
CLOUD014Norcisapride
CLOUD003Chloroquine
Selection and library evolution scheme
[1] Nature Chemical Biology 13, 771–778 (2017).