Natural Product-like Fragments

Source of biologically validated starting points

4 160 compounds

Screening of natural products has inspired discovery of remarkable number of drugs. Enrichment of small libraries with compounds possessing structural motifs validated by nature allows reaching better molecular profile and improves biological response. A special place in drug development should belong to Natural Product-like Fragments as promising starting points within attractive chemicals space.

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

NPL-4160-Y-10

Compounds

4 160
13 plates

Amount

10 µL of 10 mM DMSO stock solutions

Plates and formats

384-well microplates, first two and last two columns empty, 320 compounds per plate

Price

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Catalog No.

NPL-4160-X-50

Compounds

4 160
52 plates

Amount

50 µL of 100 mM DMSO stock solutions

Plates and formats

96-well plates, Greiner, first and last columns empty

Price

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Catalog No.

NPL-4160-X-100

Compounds

4 160
52 plates

Amount

100 µL of 10 mM DMSO stock solutions

Plates and formats

96-well microplates, 80 compounds per plate

Price

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Catalog No.

NPL-4160

Compounds

4 160

Amount

Custom

Plates and formats

Any custom format

Price

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Get more details

Download SD file

Natural Product-like Fragments

Library code: NPL-4160

Version: 02 Jun 2020

4 160 compounds
at 100 mM in DMSO

Key features

  • Scaffold Tree approachwas applied to the Universal Natural Product Database (UNPD) comprising over 200K compounds to extract initial Scaffold Set.
  • MedChem structural filters and refinements were used in order to remove trivial chemotypes, PAINS and overpopulated cores resulting in the Reference Scaffold Setwith 550 structures.
  • Substructure and similarity searches were applied to extract compounds bearing natural-like cores and moieties. Scaffold frequency analysiswas carried out to finalize and optimize fragment library.

Examples of the molecules

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