Hit Locator Library
The largest diversity library with high MedChem tractability
460 160 compounds
Hit Locator Library (HLL) represents the entire Enamine’s Screening Collection of 4M+ compounds. Smart clustering approach and elaborated MedChem filters together with thoughtful molecular parameters restriction allowed us to design an ultimate HTS Library.
Typical Formats
Catalog No.
HLL-460-0-Y-2
Compounds
460 160
1 438 plates
Amount
≤ 150 nL of 2 mM DMSO solutions
Plates and formats
384-well microplates, Greiner Bio-One #78407;
first two and last two columns empty;
320 compounds per plate
Price
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Catalog No.
HLL-200-0-Z-10
Compounds
200 000
157 plates
Amount
≤ 150 nL of 10 mM DMSO solutions
Plates and formats
1536-well microplates, Corning #4372;
first and last four columns empty;
1280 compounds per plate
Price
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Catalog No.
HLL-300-10-Y-10
Compounds
300 160
938 plates
Amount
10 μL of 10 mM DMSO solutions
Plates and formats
384-well plates, Greiner #784201;
1,2 and 23,24 columns empty;
320 compounds per plate
Price
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Catalog No.
HLL-460
Compounds
460 160
Amount
Custom
Plates and formats
Any custom format
Price
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Library design
Carefully considered approach to the design our largest screening library aims to deliver the most reliable source of initial hits. Each compound in the library passed stringent MedChem filters and QC control. Construction of this HTS Library allow to get initial SAR data immediately after a first screen and will help you to determine safe hits, which you can follow more secure than any other from commercial diversity libraries. The main focus at medicinal chemistry hand was fixed on the lead-like molecules to give more space for evolution of identified hits. At the same time, we were trying to focus on robust chemistry, which should not bring troubles with synthesis of scaffolds or their derivatisation. Our deep knowledge in synthetic chemistry already over 25 years’ experience allowed us to rate molecules by synthetic feasibility, which has been used as additional evaluation in the design of the largest Enamine Screening Library.
Key features
- No singletons, at least 3 compounds per cluster
- Immediate initial SAR, scaffold-secured
- Represents entire Enamine Screening Collection
- Lead-like compounds
- Hit confirmation & follow-up support
Along with all industry affiliated MedChem filters, sieve visual control of the core scaffolds (over 47k) have been applied. We believe that our effort will bring you a valuable hits. Some examples are represented below
Example of a cluster series

Cluster 458692

Cluster 103875
Molecular properties







