Hit Locator Library

The largest diversity library with high MedChem tractability

460 320 compounds

Hit Locator Library (HLL) represents the entire Enamine’s Screening Collection of 3 Million compounds. Smart clustering approach and elaborated MedChem filters together with thoughtful molecular parameters restriction allowed us to design an ultimate HTS Library.

HLL available for prompt delivery in various plated formats including the most popular listed below:

Possible formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

HLL-460-0-Y-2

Compounds

460 320
1 439 plates

Amount

≤ 150 nL of 2 mM DMSO solutions

Plates and formats

384-well microplates, Greiner Bio-One #78407;
first two and last two columns empty;
320 compounds per plate

Price

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Catalog No.

HLL-200-0-Z-10

Compounds

200 000
157 plates

Amount

≤ 150 nL of 10 mM DMSO solutions

Plates and formats

1536-well microplates, Corning #4372;
first and last four columns empty;
1280 compounds per plate

Price

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Catalog No.

HLL-300-10-Y-10

Compounds

300 160
938 plates

Amount

10 μL of 10 mM DMSO solutions

Plates and formats

384-well plates, Greiner #784201;
1,2 and 23,24 columns empty;
320 compounds per plate

Price

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Catalog No.

HLL-460-25-Y-10

Compounds

460 320
1 308 plates

Amount

25 µL of 10 mM DMSO solutions

Plates and formats

384-well acoustic plates, Labcyte #PP-0200;
last two columns empty;
352 compounds per plate

Price

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Catalog No.

HLL-100-50-X-10

Compounds

100 160
1 252 plates

Amount

50 µL of 10 mM DMSO solutions

Plates and formats

96-well plates, Greiner #65021;
1 and 12 columns empty;
80 cmpds per plate

Price

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Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

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Library design

Carefully considered approach to the design our largest screening library aims to deliver the most reliable source of initial hits. Each compound in the library passed stringent MedChem filters and QC control. Construction of this HTS Library allow to get initial SAR data immediately after a first screen and will help you to determine safe hits, which you can follow more secure than any other from commercial diversity libraries. The main focus at medicinal chemistry hand was fixed on the lead-like molecules to give more space for evolution of identified hits. At the same time, we were trying to focus on robust chemistry, which should not bring troubles with synthesis of scaffolds or their derivatisation. Our deep knowledge in synthetic chemistry already over 25 years’ experience allowed us to rate molecules by synthetic feasibility, which has been used as additional evaluation in the design of the largest Enamine Screening Library.

Key features

  • No singletons, at least 3 compounds per cluster
  • Immediate initial SAR, scaffold-secured
  • Represents entire Enamine Screening Collection
  • Lead-like compounds
  • Hit confirmation & follow-up support

Along with all industry affiliated MedChem filters, sieve visual control of the core scaffolds (over 47k) have been applied. We believe that our effort will bring you a valuable hits. Some examples are represented below

Example of a cluster series

Cluster 458692

Cluster 103875

Molecular properties

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