Tris(2-carboxyethyl)phosphine hydrochloride

CAS 51805-45-9, Cat. No EN300-1724932
Reagent for reduction of S- and N-containing compounds

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Tris(2-carboxyethyl)phosphine hydrochloride (TCEP hydrochloride) is a versatile reagent that can reduce disulfides, sulfoxides, sulfonyl chlorides, N-oxides, and azides¹. It is a white crystalline solid well soluble in water. The reagent is air-stable, water-soluble, odorless. It is also pH tolerant, buffers in aqueous media, and tolerates a variety of functional groups under synthetic, biological, and physiological conditions as a reducing reagent. TCEP hydrochloride is a suitable reducing agent for the Staudinger reaction in bioconjugation and peptide ligation and it is often employed for thiol (as disulfide) deprotection.

Synonyms: TCEP hydrochloride; TCEP-HCl; propanoic acid, 3,3′,3′′-phosphinidynetris-, hydrochloride; 3,3',3''-phosphinetriyltripropanoic acid hydrochloride