Tris(2,2,2-trifluoroethoxy)boron

CAS 659-18-7, Cat. No EN300-18543889
Reagent for amide coupling

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Tris(2,2,2-trifluoroethoxy)boron, also known as the Sheppard amidation reagent, is a highly effective amide coupling agent, used to form amides from carboxylic acids and amines¹. It operates under mild conditions and after the reaction completion, there is no need for aqueous workup or chromatography because the filtration is enough for efficient product separation. The reagent is a colorless liquid, soluble in most organic solvents, and should be handled with care due to its irritant and flammable nature.

Synonyms: Sheppard amidation reagent; boric acid tris(2,2,2-trifluoroethyl) ester; tris(2,2,2-trifluoroethoxy)boron; tris(2,2,2-trifluoroethyl) borate; TTFEB