CAS 94790-35-9, Cat. No EN300-7361941
Reagent-activator for carboxylic group
TCHF is a reliable reagent-activator in tandem with N-methylimidazole (NMI) that usually applies to reactions with weak nucleophiles. It is a white solid that is soluble in common organic solvents. The reaction conditions are soft, but in some cases, moderate heating is required. Sterically and electronically diverse anilines, as well as heteroaryl amines, all can be coupled in reasonable reaction times and good yields, even when the reactions are run under air. Also, this coupling technique is perfect for hindered carboxylic group.
Synonyms: Tetramethylchloroformamidinium hexafluorophosphate