CAS 2179072-33-2, Cat. No EN300-6734306
Reagent for sulfofluorination
Fluorosulfuryl imidazolium triflate salt (SuFEx-IT) is a click-chemistry reagent that is a much safer analog of SO2F2 gas, offering simpler procedures and less hazard to health. SuFEx-IT also possesses greater reactivity and selectivity compared to SO2F21. The F-SO2+ fragment attaches to H-containing acceptor groups such as phenols and amines to give fluorosulfates and sulfoamoyl fluorides respectively with good yields2,3.
Synonyms: 1-(fluorosulfonyl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate; fluorosulfuryl imidazolium triflate salt; SuFEx-IT
Selected publications
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A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope.
Guo T.; Meng G.; Zhan X.; Yang Q.; Ma T.; Xu L.; Sharpless K.; Dong J. Angewandte Chemie International Edition 2018, 57 (10), 2605–2610. DOI: 10.1002/anie.201712429
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Modular Click Chemistry Libraries for Functional Screens Using a Diazotizing Reagent.
Meng G.; Guo T.; Ma T.; Zhang J.; Shen Y.; Sharpless K.; Dong J. Nature 2019, 574 (7776), 86–89. DOI: 10.1038/s41586-019-1589-1
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Emerging Utility of Fluorosulfate Chemical Probes.
Jones L. ACS Med Chem Lett 2018, 9 (7), 584–586. DOI: 10.1021/acsmedchemlett.8b00276