CAS 878376-35-3, Cat. No EN300-244367
Reagent for the deoxofluorination
Pyridine-2-sulfonyl fluoride, widely known as PyFluor, serves as a reliable reagent for the fluorination of alcohols, offering outstanding stability and a simple reaction procedure. It represents an advancement over the traditional DAST reagent, primarily designed to enhance selectivity against elimination reactions, thereby facilitating efficient and straightforward purification processes. Unlike DAST, which often yields elimination side products and exhibits poor thermal stability, PyFluor excels in avoiding such issues, resulting in higher reaction yields. PyFluor also tolerates a broad range of basic functionalities including phthalimides, heterocycles, and even unprotected amines and anilines. Most reactions proceeded at room temperature, although cyclic or sterically encumbered substrates require moderate heating. This combination of selectivity, safety, and cost-effectiveness makes PyFluor an ideal choice for deoxyfluorination on a preparatory scale.
Synonyms: PyFluor, 2-Pyridinesulfonyl fluoride, Pyridine-2-sulfonyl fluoride